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Polymeric drug delivery systems by additive manufacturing.
Sedigheh Borandeh1, Bas van Bochove1, Arun Teotia1
1Polymer Technology, School of Chemical Engineering, Aalto University, Espoo 02150, Finland.
Advanced Drug Delivery Reviews
|April 8, 2021
Summary
Additive manufacturing (AM) offers new ways to create advanced polymer drug delivery systems. This technology enables complex designs for controlled drug release, improving safety and patient outcomes.
Area of Science:
- Polymer science and materials engineering
- Pharmaceutical sciences
- Additive Manufacturing (AM) technologies
Background:
- Additive manufacturing (AM) is increasingly utilized in drug delivery.
- Polymer-based systems enhance drug safety, efficacy, and patient compliance.
- AM and polymers offer solutions to limitations in controlled-release drug delivery.
Purpose of the Study:
- To review recent advancements in polymeric drug delivery systems fabricated using AM.
- To provide a comprehensive overview from a polymer-AM perspective.
- To discuss materials, properties, design, fabrication, and release mechanisms.
Main Methods:
- Literature review of polymer-AM drug delivery systems.
- Analysis of materials, properties, and fabrication techniques.
- Examination of controlled release mechanisms and design strategies.
Main Results:
- AM enables complex geometries for tailored drug release profiles.
- Polymeric materials are crucial for AM-based drug delivery systems.
- Various fabrication techniques and release mechanisms are discussed.
Conclusions:
- Combining polymers and AM presents significant advantages for controlled drug delivery.
- Challenges and future prospects for personalized medicine and clinical applications are highlighted.
- This review offers a holistic perspective on polymer-AM for drug delivery systems.
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