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[Sleep-disordered breathing in patients with chronic heart failure before and after heart transplantation]

Z F Zeng1, Z W Wang2, H H Mo1

  • 1Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases
|April 8, 2021
PubMed

Insights

Patients awaiting heart transplants frequently experience sleep-disordered breathing (SDB), particularly Cheyne-Stokes respiration. Heart transplantation significantly improves SDB, often eliminating Cheyne-Stokes respiration.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Sleep-disordered breathing (SDB) is common in patients with chronic heart failure (CHF).
  • Cheyne-Stokes respiration (CSR) is a specific type of SDB often seen in CHF.
  • The impact of heart transplantation on SDB in CHF patients requires further investigation.

Purpose of the Study:

  • To characterize SDB in CHF patients awaiting heart transplantation.
  • To evaluate the changes in SDB following heart transplantation.

Main Methods:

  • Prospective study of 34 CHF patients awaiting heart transplantation.
  • Portable sleep physiological monitoring used for SDB assessment before and after transplantation.
  • Analysis of SDB characteristics, including CSR, and correlation with left ventricular ejection fraction (LVEF).

Main Results:

  • High prevalence of SDB (26/34 patients) before transplantation, with central sleep apnea (CSA) and CSR being the predominant types.
  • CSR cycle length showed a negative correlation with LVEF.
  • Significant improvement in SDB, including elimination of CSR, observed in 15 patients post-transplantation.

Conclusions:

  • CHF patients awaiting heart transplantation exhibit a high incidence of SDB, primarily CSA with CSR.
  • Heart transplantation demonstrates a therapeutic effect, potentially eliminating CSR in these patients.

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