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Updated: Nov 9, 2025

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
Published on: August 4, 2021
Implementing less invasive surfactant administration on a neonatal unit
Sarah Louise Williamson1, Helen McDermott2, Harsha Gowda2
1Neonatal Unit, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK sarahlouise.williamson@nhs.net.
Abstract:
There is increasing evidence reflected in both UK 2019 NICE and European guidelines suggesting that less invasive surfactant administration (LISA) reduces the need for mechanical ventilation and reduces the combined outcome of death or bronchopulmonary dysplasia, and is now the optimal method for surfactant delivery in spontaneously breathing babies. Despite this, uptake in England has been slow compared with Europe. This quality improvement project outlines the process of implementing LISA in a neonatal intensive care unit over a 2-year period, the barriers and challenges which were encountered, and how they were overcome.
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