Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D bioprinting of alginate/gelatin hydrogels with tunable mechanical properties for skeletal muscle regeneration.

Biomaterials advances·2026
Same author

Distributed spatial awareness for robot swarms.

Autonomous robots·2025
Same author

3D Bioprinted Engineered Living Microreactors for Continuous Organophosphorus Compound Degradation.

Small science·2025
Same author

Hybrid diacrylate resin-gelatin methacryloyl composite with bone-to-brain stiffness range.

Communications materials·2025
Same author

The Immobilization of Hyaluronic Acid in 3D Hydrogel Scaffolds Modulates Macrophage Polarization.

Advanced biology·2025
Same author

Consensus in the weighted voter model with noise-free and noisy observations.

Swarm intelligence·2025

Related Experiment Video

Updated: Nov 9, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.5K

Measuring Nanoparticle Penetration Through Bio-Mimetic Gels.

Scott C McCormick1, Namid Stillman1, Matthew Hockley1

  • 1Engineering Mathematics, University of Bristol, Bristol, BS8 1UB, UK.

International Journal of Nanomedicine
|April 9, 2021
PubMed
Summary

We developed a low-cost microfluidic chip to track nanoparticle transport in tumor tissue. This method reveals how nanoparticle size and surrounding microparticles affect their penetration, aiding nanocarrier design.

Keywords:
fast-prototypingimage processingmicrofluidicsnanomedicinetissue penetrationtransport barriers

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.4K
Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
09:34

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

3.5K

Related Experiment Videos

Last Updated: Nov 9, 2025

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

1.5K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.4K
Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
09:34

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

3.5K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Nanocarriers are crucial for targeted drug delivery in cancer nanomedicine.
  • Efficient drug transport relies on nanocarriers overcoming biological barriers to reach tumor sites.
  • Visualizing in vivo nanocarrier dynamics is challenging, and in vitro models often lack relevant constraints.

Purpose of the Study:

  • To develop a simple, low-cost method for observing nanoparticle transport dynamics in tissue.
  • To analyze nanocarrier penetration through a tissue-mimetic microfluidic chip.
  • To understand the influence of physical constraints on nanoparticle movement.

Main Methods:

  • A microfluidic chip was designed to mimic tumor tissue.
  • Fluorescent nanoparticles were tracked through hydrogels (Matrigel and Collagen I) with and without microparticles.
  • Bespoke MATLAB software was used for image processing and statistical analysis of nanoparticle tracking.

Main Results:

  • The method demonstrated size-dependent transport mechanics of nanoparticles.
  • Fluorescein dye diffused within 8 hours, while 20 nm nanoparticles showed hindered diffusion in hydrogels.
  • Statistical analysis confirmed the significant impact of nanoparticle size and microparticle presence on penetration depth.

Conclusions:

  • The developed method offers an accessible way to measure nanoparticle tissue penetration.
  • This facilitates initial steps towards automated experimentation for nanocarrier design.
  • Enables rational design of nanocarriers with improved transport dynamics.