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Does Parathyroidectomy Affect the Neutrophil/Lymphocyte Ratio, a Systemic Inflammatory Marker?
Hüseyin Alakuş1, Mustafa Göksu2
1Department of Surgical Oncology, Adiyaman University Faculty of Medicine, Adiyaman, TUR.
Cureus
|April 9, 2021
Summary
Primary hyperparathyroidism (PHPT) is linked to inflammation. Successful parathyroidectomy significantly reduces the neutrophil-to-lymphocyte ratio (NLR), indicating decreased systemic inflammation in PHPT patients.
Area of Science:
- Endocrinology
- Inflammation markers
Background:
- Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by elevated parathyroid hormone levels.
- PHPT is associated with increased systemic inflammation, potentially indicated by elevated neutrophil-to-lymphocyte ratio (NLR).
Purpose of the Study:
- To evaluate the impact of parathyroidectomy on NLR and inflammatory markers in PHPT patients.
- To assess changes in serum parathormone, calcium, phosphate, and white blood cell (WBC) count post-parathyroidectomy.
Main Methods:
- A cohort of 37 patients with PHPT undergoing parathyroidectomy was studied.
- NLR, serum parathormone, corrected calcium, phosphate, and WBC count were measured before surgery and at 6 months post-surgery.
Main Results:
- Successful parathyroidectomy led to a statistically significant decrease in NLR, serum parathormone, serum corrected calcium, and serum phosphate.
- No significant change was observed in WBC count post-surgery.
- Pre-operative NLR correlated positively with serum parathormone, serum corrected calcium, and WBC count, and negatively with serum phosphate.
Conclusions:
- Parathyroidectomy effectively reduces NLR in PHPT patients.
- Surgical treatment of PHPT can mitigate associated systemic inflammation.
