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Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
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Vaccination and Immunotherapy for Major Depression.
Alper Evrensel1, Barış Önen Ünsalver2, Mehmet Emin Ceylan3
1Department of Psychiatry, NP Brain Hospital, Saray Mah. Ahmet Tevfik İleri Cad. No: 18 PK:34768 Umraniye, Uskudar University, Istanbul, Turkey. alperevrensel@gmail.com.
Advances in Experimental Medicine and Biology
|April 9, 2021
Summary
Neuroinflammation plays a key role in depression development. This review explores how targeting immune dysfunction through vaccination and immunotherapy may offer new depression treatment strategies.
Area of Science:
- Psychiatry
- Immunology
- Neuroscience
Background:
- Depression is a common disorder with complex causes, including genetic, environmental, and immunological factors.
- Current antidepressant treatments are insufficient, failing to achieve 100% efficacy and leaving a significant portion of patients with treatment-resistant depression or experiencing relapse.
- Recent research highlights the role of immune dysfunction and neuroinflammation in understanding and treating depression.
Purpose of the Study:
- To review the role of neuroinflammation in the etiopathogenesis of major depression.
- To discuss the potential of vaccination and immunotherapy as novel treatment strategies for depression.
Main Methods:
- Literature review focusing on the link between neuroinflammation and depression.
- Exploration of current research on immune system involvement in neuropsychiatric disorders.
- Analysis of emerging vaccination and immunotherapy approaches for depression.
Main Results:
- Growing evidence suggests a causal relationship between chronic, low-level neuroinflammation and the development of major depression.
- Understanding the extraneuronal components of depression is advancing with improved immunological insights and technological capabilities.
Conclusions:
- Neuroinflammation is a significant factor in depression's origins.
- Vaccination and immunotherapy present promising avenues for future depression treatment and management.
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