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[A new hypothesis on vascular calcification: the exhausting buffer syndrome (EBS)].

Andras Sikter1, Christian Sonne

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Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet Lapja = Official Journal of the Hungarian Association of Psychopharmacology
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Summary

Western lifestyle disrupts phosphate metabolism through diet and stress, leading to insulin resistance and vascular calcification. Lowering calorie intake and acidic foods may help mitigate these effects.

Keywords:
Cardiometabolic SyndromeExhausting Buffer Syndromeintracellular acidosissocial defeat

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Area of Science:

  • Metabolic disorders
  • Vascular health
  • Lifestyle medicine

Background:

  • Western lifestyle, characterized by caloric/acidic hyperphagia and psychosocial stress, is implicated in disrupting phosphate metabolism.
  • Psychic factors like social defeat contribute to reduced activity and chronic hypoventilation (hypercapnia), impacting homeostasis.

Purpose of the Study:

  • To propose mechanisms by which lifestyle factors disrupt phosphate metabolism and contribute to vascular damage.
  • To investigate the link between phosphate metabolism disruption, insulin resistance, and vascular calcification.

Main Methods:

  • Conceptual framework integrating lifestyle, psychic factors, and metabolic pathways.
  • Analysis of proposed mechanisms involving intracellular acidosis, insulin resistance, and the Exhausting Buffer Syndrome (EBS).

Main Results:

  • Two primary mechanisms link lifestyle to harmful phosphate effects: 1) Insulin resistance (Cardiometabolic Syndrome) via chronic hypercapnic acidosis, and 2) Elevated serum inorganic phosphate (Exhausting Buffer Syndrome) via fixed acid overload.
  • These pathways, influenced by genetics, contribute to vascular calcification.

Conclusions:

  • Disrupted phosphate metabolism, driven by Western lifestyle and psychosocial factors, underlies significant health issues.
  • Potential solutions include reduced calorie and acid intake, alongside promoting hypocapnia.