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Databases for RNA Editing Collections.

Claudio Lo Giudice1, Luigi Mansi1, Graziano Pesole1,2,3,4

  • 1Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari, Bari, Italy.

Methods in Molecular Biology (Clifton, N.J.)
|April 9, 2021
PubMed
Summary

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This summary is machine-generated.

Adenosine-to-inosine (A-to-I) RNA editing impacts gene expression and human health. This study reviews RNA editing databases and highlights REDIportal, the largest A-to-I event collection.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • A-to-I RNA editing influences gene expression and proteome diversity in humans.
  • Deregulation of A-to-I editing is implicated in diseases like neurological disorders and cancer.
  • RNA sequencing (RNAseq) has advanced the study of RNA editing at single nucleotide resolution.

Purpose of the Study:

  • To provide an overview of current RNA editing databases.
  • To introduce REDIportal as a comprehensive resource for A-to-I editing events.

Main Methods:

  • Literature review of existing RNA editing databases.
  • Analysis of data from GTEx samples for REDIportal construction.

Main Results:

Keywords:
A-to-I editingDatabaseREDIportalRNA editingRNAseqTranscriptomics

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  • Multiple bioinformatics resources for discovering RNA editing events are available.
  • REDIportal is presented as the largest collection of A-to-I events.
  • REDIportal contains over 4.5 million A-to-I sites from 2660 human GTEx samples.

    • Conclusions:

    • REDIportal offers a valuable, large-scale resource for A-to-I RNA editing research.
    • Understanding A-to-I editing is crucial for advancing human health and disease research.