Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hedonic impact of cleaner-client fish interactions is mediated by the opioid system.

Proceedings. Biological sciences·2025
Same author

Client reef fish prefer more blue-saturated cleaner wrasses Labroides dimidiatus.

The Journal of experimental biology·2025
Same author

Individual differences in response to alcohol and nicotine in zebrafish: Gene expression and behavior.

Development, growth & differentiation·2023
Same author

Embryonic ethanol exposure on zebrafish early development.

Brain and behavior·2021
Same author

Damselfish face climate change: Impact of temperature and habitat structure on agonistic behavior.

PloS one·2020
Same author

Memory retention of appetitive and aversive conditioning in the damselfish Stegastes fuscus.

Journal of fish biology·2019

Related Experiment Video

Updated: Nov 9, 2025

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior
04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

Published on: February 9, 2024

506

Does early ethanol exposure increase seeking-like behavior in zebrafish?

Jaquelinne Pinheiro-da-Silva1, Heloysa Araujo-Silva1, Ana Carolina Luchiari1

  • 1Departamento de Fisiologia e Comportamento, Universidade Federal do Rio Grande do Norte, Natal, Brazil.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|April 10, 2021
PubMed
Summary

Early alcohol exposure in zebrafish embryos disrupts associative learning and alcohol preference later in life. This suggests potential neurological deficits contributing to alcohol-related neurodevelopmental disorders (ARND).

Keywords:
ARNDalcoholseeking-like behaviorzebrafish

More Related Videos

A Novel Method of Drug Administration to Multiple Zebrafish Danio rerio and the Quantification of Withdrawal
10:52

A Novel Method of Drug Administration to Multiple Zebrafish Danio rerio and the Quantification of Withdrawal

Published on: November 12, 2014

12.4K
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

26.8K

Related Experiment Videos

Last Updated: Nov 9, 2025

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior
04:58

Modeling Fetal Alcohol Spectrum Disorders in Zebrafish to Characterize the Impact of an Adverse Embryonic Environment on Adult Social Behavior

Published on: February 9, 2024

506
A Novel Method of Drug Administration to Multiple Zebrafish Danio rerio and the Quantification of Withdrawal
10:52

A Novel Method of Drug Administration to Multiple Zebrafish Danio rerio and the Quantification of Withdrawal

Published on: November 12, 2014

12.4K
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

26.8K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Toxicology

Background:

  • Fetal alcohol spectrum disorder (FASD) is a leading cause of birth defects, with alcohol-related neurodevelopmental disorder (ARND) being a frequent and difficult diagnosis.
  • ARND is associated with cognitive deficits, impaired social behavior, and increased risk of addiction.
  • Zebrafish serve as a valuable model for studying embryonic alcohol exposure and its long-term effects.

Purpose of the Study:

  • To investigate if early embryonic alcohol exposure influences later alcohol preference in zebrafish.
  • To test the hypothesis that early alcohol exposure enhances the reinforcing effects of alcohol, increasing addiction risk.

Main Methods:

  • Zebrafish embryos were exposed to 0.0%, 0.25%, or 0.5% alcohol for 2 hours at 24 hours post-fertilization.
  • Conditioned place preference was assessed in fry (10 dpf) and young (90 dpf) zebrafish.
  • Evaluated the impact of embryonic alcohol exposure on associative learning related to alcohol.

Main Results:

  • Control zebrafish demonstrated alcohol associative learning at both fry and young stages.
  • Embryonic exposure to 0.25% and 0.5% alcohol resulted in a lack of conditioning response at all evaluated stages.
  • These findings indicate that early alcohol exposure can impair perception and cognitive deficits.

Conclusions:

  • Embryonic alcohol exposure, even at low doses without malformations, can lead to neurological and behavioral changes characteristic of ARND.
  • These deficits may alter alcohol responsiveness and associative learning throughout life.
  • Results provide insights into how embryonic alcohol exposure affects neurocircuitry involved in perception and learning.