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Development of 148Gd analysis method using stable Gd
Grzegorz Olszewski1, Patric Lindahl2, Peter Frisk2
1Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine, 581 83, Linköping, Sweden; Swedish Radiation Safety Authority, Solna strandväg 96, 171 54, Solna, Sweden; University of Gdańsk, Faculty of Chemistry, Department of Environmental Chemistry and Radiochemistry, Laboratory of Toxicology and Radiation Protection, Wita Stwosza 63, 80-308, Gdańsk, Poland.
A new analytical method was developed to measure Gadolinium-148 (¹⁴⁸Gd) in environmental and biological samples. This method utilizes advanced chromatography techniques and achieves a maximum recovery of 75% for Gadolinium determination.
Area of Science:
- Environmental Chemistry
- Analytical Chemistry
- Radiochemistry
Background:
- Accurate determination of Gadolinium-148 (¹⁴⁸Gd) is crucial for environmental monitoring and bioassay.
- Existing analytical methods may require refinement for specific sample matrices.
Purpose of the Study:
- To develop and validate a robust analytical method for ¹⁴⁸Gd determination.
- To enable accurate quantification of ¹⁴⁸Gd in diverse environmental and bioassay samples.
Main Methods:
- Utilized a combination of anion exchange resin, extraction chromatography, and cation exchange resin.
- Employed alkaline fusion for solid sample dissolution and calcium oxalate co-precipitation for liquid sample preconcentration.
- Validated the method using natural Gadolinium (¹⁵⁷Gd) and Inductively Coupled Plasma - Triple Quadrupole Mass Spectrometry (ICP-QQQ-MS).
Main Results:
- Successfully developed a multi-step chromatographic method for Gd separation and purification.
- Achieved a maximum total method recovery of 75% for Gadolinium determination.
- Demonstrated the applicability of the method for environmental and bioassay samples.
Conclusions:
- The developed analytical method provides a reliable approach for ¹⁴⁸Gd quantification.
- The method's effectiveness in sample preparation and purification was confirmed.
- Further application of this method can enhance environmental surveillance and human exposure assessments related to Gadolinium isotopes.
