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Related Experiment Video

Updated: Nov 9, 2025

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

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Published on: October 31, 2025

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Critical Closing Pressure by Diffuse Correlation Spectroscopy in a Neonatal Piglet Model.

Leah I Elizondo1, Eric L Vu2, Kathleen K Kibler1

  • 1Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.

Acta Neurochirurgica. Supplement
|April 11, 2021
PubMed
Summary
This summary is machine-generated.

Critical closing pressure (CrCP) estimation is vital for preterm infants. Diffuse correlation spectroscopy (DCS) and transcranial Doppler (TCD) ultrasound showed good correlation in measuring CrCP in a neonatal piglet model.

Keywords:
Cerebral blood flowCritical closing pressureDiffuse correlation spectroscopyPrematurityTranscranial Doppler ultrasound

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Area of Science:

  • Neonatal physiology
  • Cerebrovascular autoregulation
  • Biomedical engineering

Background:

  • Critical closing pressure (CrCP) is the arterial blood pressure (ABP) at which cerebral blood flow (CBF) ceases.
  • Preterm infants have low ABP near their CrCP, leading to diastolic no-flow, making CrCP estimation clinically significant.
  • Transcranial Doppler (TCD) ultrasound is a current method for estimating CrCP in preterm infants.

Purpose of the Study:

  • To compare and validate the critical closing pressure (CrCP) measured by diffuse correlation spectroscopy (DCS) against TCD ultrasound.
  • To assess the feasibility of DCS for continuous, noninvasive measurement of microvascular CBF in a neonatal setting.

Main Methods:

  • Hemorrhagic shock was induced in 13 neonatal piglets.
  • Cerebral blood flow (CBF) was continuously measured using both DCS and TCD ultrasound.
  • CrCP was calculated using a cerebrovascular impedance model.

Main Results:

  • CrCP measurements by DCS and TCD ultrasound demonstrated good correlation (median r² = 0.8).
  • Bland-Altman analysis revealed a median bias of -3.5 between the two modalities.
  • This study represents the first comparison of DCS and TCD for CrCP in a neonatal piglet hemorrhagic shock model.

Conclusions:

  • DCS shows promise as a validated method for estimating critical closing pressure (CrCP) in neonates.
  • Observed differences in CrCP may stem from microvascular versus macrovascular vasomotor tone variations.
  • Further research is warranted to understand the implications of these differences in clinical practice.