Proteomics applications in biomarker discovery and pathogenesis for abdominal aortic aneurysm

Area of Science:

• Biochemistry
• Medical Science
• Proteomics

Background:

• Abdominal aortic aneurysm (AAA) is a prevalent, severe vascular condition with poorly understood pathogenesis.
• Current clinical applications lack specific biomarkers and drugs for AAA management.
• Proteomics offers a powerful approach for biomarker discovery, pathogenesis research, and identifying drug targets in AAA.

Purpose of the Study:

• To review the application of mass spectrometry-based proteome analysis in abdominal aortic aneurysm (AAA) over the past decade.
• To identify differentially expressed proteins and potential biomarkers, pathogenic mechanisms, and therapeutic targets for AAA.
• To discuss the challenges and future prospects of proteomics in AAA research.

Main Methods:

• Mass spectrometry-based proteome analysis.
• Analysis of diverse sample sources including vascular tissue, intraluminal thrombus, secretome, blood, and cells from AAA patients.
• Review of proteomic studies conducted within the last ten years.

Main Results:

• Identification of differentially expressed proteins associated with AAA across various sample types.
• Discovery of potential disease biomarkers, insights into pathogenic mechanisms, and potential therapeutic targets for AAA.
• Highlighting the utility of proteomic analysis in advancing AAA research.

Conclusions:

• Proteomic studies have revealed promising biomarkers and therapeutic targets for AAA.
• Validation of identified biomarkers in multicenter cohorts is crucial for clinical translation.
• Future advancements in proteomics, including modification-specific analysis and multi-omics, will deepen understanding and accelerate drug development for AAA.