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Published on: August 11, 2019
[Dynamic change of hippocampal volume in children with recurrent febrile seizures]
1Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Insights
Hippocampal volume (HCV) increases with age in children experiencing recurrent febrile seizures. Persistent seizures may negatively impact hippocampal development, highlighting the importance of monitoring HCV in these children.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Radiology
Background:
- Recurrent febrile seizures (RFS) are common in childhood.
- The hippocampus is crucial for memory and learning.
- Understanding hippocampal volume (HCV) changes in RFS is vital for prognosis.
Purpose of the Study:
- To investigate the changes and significance of hippocampal volume (HCV) in children with recurrent febrile seizures.
- To analyze the correlation between HCV and age, follow-up duration, and seizure persistence.
Main Methods:
- Retrospective analysis of 34 children with RFS.
- Two MRI scans of the hippocampus were performed between January 2013 and September 2019.
- Children were grouped by follow-up time and seizure prognosis (febrile seizure, non-febrile seizure, epilepsy).
Main Results:
- Total HCV positively correlated with age (r=0.683, P < 0.05).
- The second follow-up group showed significantly larger total HCV than the first.
- Preschoolers (≥3 years) had larger HCV (total, left, right) than younger children (<3 years).
- Children with persistent seizures had a significantly lower average annual increment (ΔV) of HCV compared to those without.
Conclusions:
- Hippocampal volume (HCV) demonstrates a gradual increase with age in children with recurrent febrile seizures.
- Persistent seizures may adversely affect hippocampal development, indicated by reduced annual volume increment.
Objective:
To study the change and significance of hippocampal volume (HCV) in children with recurrent febrile seizures.
Methods:
A retrospective analysis was performed on the medical data and examination results of 34 children with recurrent febrile seizures who underwent two magnetic resonance plain scans of the head and the hippocampus from January 1, 2013 to September 30, 2019. According to the follow-up time, they were divided into the first follow-up group and the second follow-up group. According to prognosis, they were divided into a febrile seizure group, a non-febrile group and an epilepsy group. The change in HCV was analyzed and compared.
Results:
Total HCV was positively correlated with age (r=0.683, P < 0.05). The second follow-up group had a significantly larger total HCV than the first follow-up group (P < 0.05). For both groups, preschool children (≥ 3 years old) had significantly larger total HCV, left HCV, and right HCV than those at an age of < 3 years (P < 0.05). For both groups, the children with persistent seizures had significantly lower average annual increment (ΔV) of total HCV, left HCV, and right HCV than those without persistent seizures (P < 0.05). There was no significant difference in ΔV of total HCV, left HCV, and right HCV among the febrile seizure, non-febrile seizure and epilepsy groups (P > 0.05).
Conclusions:
HCV gradually increases with age in children with recurrent febrile seizures. Persistent seizures may damage the development of the hippocampus.
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