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RNA Interference

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...

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Related Experiment Video

Updated: Nov 9, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

Published on: March 24, 2015

Interferon therapies in small animals.

Ralf S Mueller¹, Katrin Hartmann¹

¹Center for Clinical Veterinary Medicine, LMU Munich, Veterinaerstr. 13, 80539 Munich, Germany.

Veterinary Journal (London, England : 1997)

|April 12, 2021

Summary

This summary is machine-generated.

Interferons (IFNs) show promise in treating certain pet diseases. Canine interferon-gamma and feline interferon-omega are effective for specific conditions in dogs and cats, but more research is needed for broader applications.

Keywords:

Cat Dog IFN-α IFN-γ IFN-ω

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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

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Last Updated: Nov 9, 2025

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Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

Published on: June 14, 2018

Area of Science:

Immunology
Veterinary Medicine
Cytokine Therapy

Background:

Interferons (IFNs) are crucial cytokines involved in immune responses in both humans and animals.
Various studies have explored the therapeutic potential of human, canine, and feline IFNs for treating infectious, inflammatory, and neoplastic conditions in companion animals.
The efficacy of IFNs in veterinary medicine is an area of ongoing research and clinical interest.

Purpose of the Study:

To review and evaluate the use of different types of interferons (human, canine, feline) as therapeutic agents for various diseases in dogs and cats.
To assess the current evidence supporting the use of recombinant IFNs for specific veterinary conditions.
To identify areas where further research, particularly large randomized controlled trials, is needed.

Main Methods:

A review of existing scientific literature and studies.
Evaluation of data on the efficacy of human, canine, and feline interferons in treating animal diseases.
Assessment of evidence for specific conditions such as canine atopic dermatitis, parvoviral enteritis, gingivitis, and keratoconjunctivitis sicca.

Main Results:

Recombinant canine interferon-gamma (IFN-γ) is effective for canine atopic dermatitis.
Recombinant feline interferon-omega (IFN-ω) shows efficacy against canine parvoviral enteritis and is recommended for canine atopic dermatitis.
Limited evidence suggests recombinant canine interferon-alpha (IFN-α) may be a topical option for canine gingivitis and keratoconjunctivitis sicca.

Conclusions:

Specific recombinant interferons demonstrate efficacy for particular diseases in dogs and cats.
Further large-scale randomized controlled trials are necessary to establish conclusive evidence for other indications and to support broader recommendations for IFN therapy in veterinary medicine.