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Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
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Enhanced clinical microbiology methods in outbreak management.

John E Moore1, Beverley C Millar1

  • 1Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, UK.

Journal of Infection Prevention
|April 12, 2021
PubMed
Summary

Enhanced microbiology testing revealed how biocides performed against Pseudomonas aeruginosa during a neonatal intensive care unit outbreak. This approach identified critical soil concentrations affecting biocide efficacy and bacterial persistence, aiding outbreak management.

Keywords:
ChlorinePseudomonas aeruginosacystic fibrosisdisinfectionmethodsmicrobiology

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Area of Science:

  • Medical Microbiology
  • Infection Prevention and Control

Background:

  • Nosocomial outbreaks require effective management strategies.
  • Conventional microbiological investigations are crucial but may overlook certain aspects.
  • Pseudomonas aeruginosa bacteraemia outbreaks pose significant risks, especially in neonatal intensive care units (NICUs).

Purpose of the Study:

  • To investigate overlooked microbiological aspects of a Pseudomonas aeruginosa bacteraemia outbreak in a NICU.
  • To assess the efficacy of biocides against outbreak strains under simulated environmental conditions.
  • To determine the impact of organic soil on biocide effectiveness and bacterial persistence.

Main Methods:

  • Enhanced microbiological testing of six Pseudomonas aeruginosa isolates from a NICU outbreak.
  • Assessing biocide susceptibility of outbreak strains.
  • Evaluating the effect of organic soil on biocide efficacy and determining bacterial persistence in soil.

Main Results:

  • Biocides demonstrated effectiveness against the outbreak strains of Pseudomonas aeruginosa.
  • The study identified the critical concentration of organic soil that rendered biocides ineffective.
  • The persistence of outbreak strains within organic soil was quantified.

Conclusions:

  • Enhanced microbiological analysis beyond conventional methods provides valuable data for outbreak management.
  • Understanding the interaction between biocides, organic soils, and bacterial persistence is key to controlling nosocomial outbreaks.
  • This approach can guide infection control teams in implementing more effective strategies during outbreaks.