Related Experiment Video

Updated: Nov 9, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

10.8K

Pulmonary aspergillosis and mucormycosis in a patient with COVID-19

Andre K Johnson1, Zeron Ghazarian2, Kristina D Cendrowski3

  • 1Riverside Community Hospital, Division of Infectious Diseases, 4445 Magnolia Avenue, Riverside, CA, 92501, USA.

Medical Mycology Case Reports
|April 12, 2021
PubMed

Insights

This study reports the first combined case of invasive pulmonary aspergillosis and mucormycosis in a male COVID-19 patient. These rare, life-threatening fungal infections are critical secondary complications in intensive care unit patients.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Pulmonology

Background:

  • Invasive pulmonary aspergillosis and mucormycosis are rare, severe fungal infections.
  • These infections are often associated with conditions like diabetes, neutropenia, and corticosteroid use.
  • Both have emerged as secondary complications in COVID-19 patients, particularly those critically ill.

Observation:

  • The study presents a unique case of a male patient admitted to the intensive care unit (ICU).
  • This patient had a concurrent diagnosis of COVID-19.

Findings:

  • The patient exhibited signs of probable pulmonary aspergillosis.
  • Additionally, there was evidence suggestive of possible pulmonary mucormycosis.
  • This represents the first documented instance of combined aspergillosis and mucormycosis in a COVID-19 patient.

Implications:

  • This case highlights the potential for co-infection with multiple invasive fungal pathogens in COVID-19.
  • It underscores the importance of considering and diagnosing these rare but serious fungal infections in critically ill COVID-19 patients.
  • Further research is needed to understand the synergistic or additive risks and optimal management strategies for such co-infections.
Keywords:
AspergillosisCOVID-19InvasiveMucormycosisPulmonary

More Related Videos

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung15:01

Confocal Laser Scanning Microscopy-Based Quantitative Analysis of Aspergillus fumigatus Conidia Distribution in Whole-Mount Optically Cleared Mouse Lung

Published on: September 18, 2021

3.6K
Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

28.2K

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
466
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
573
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
458
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
818
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
1.5K
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.1K