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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.3K

Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy

Guillaume Domain1, Cecile Chouquet2, Patricia Réant3

  • 1Department of Cardiology, University Hospital Rangueil, 1 avenue Pr. Jean Poulhès 31400 Toulouse, France.

European Heart Journal. Cardiovascular Imaging
|April 12, 2021
PubMed

Insights

In hypertrophic cardiomyopathy (HCM), left ventricular mass (LVM) negatively correlates with QRS duration. Conversely, QRS duration increases with LVM in left ventricular hypertrophy (LVH) and other conditions, suggesting distinct disease mechanisms.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Cardiovascular Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) may present with narrow QRS durations.
  • Left ventricular hypertrophy (LVH) can be associated with prolonged QRS duration.
  • Understanding the relationship between QRS duration and left ventricular mass (LVM) is crucial for diagnosing cardiac conditions.

Purpose of the Study:

  • To investigate the correlation between QRS duration and LVM in different subtypes of abnormal left ventricular wall thickness.
  • To compare these relationships in hypertrophic cardiomyopathy (HCM), left ventricular non-compaction (LVNC), left ventricular hypertrophy (LVH), and healthy controls.

Main Methods:

  • Automated measurement of LVM using cardiac MRI and QRS duration using ECG.
  • Retrospective analysis of 221 HCM, 28 LVNC, 16 LVH, and 40 control subjects.
  • Uni and multivariate analyses to identify factors influencing LVM and QRS duration, and subgroup analysis of their relationship.

Main Results:

  • Significant differences in mean QRS duration and LVM were observed across groups (P < 0.01).
  • QRS duration, LVM, hypertension, maximal wall thickness, and late gadolinium enhancement were linked to HCM.
  • An independent negative correlation between LVM and QRS duration was found in HCM, unlike the positive correlation in LVNC, LVH, and controls.

Conclusions:

  • The relationship between QRS duration and LVM differs significantly between HCM and conditions like LVH or healthy hearts.
  • A reverse relationship exists in HCM, with increasing LVM associated with decreasing QRS duration.
  • These findings may aid in refining diagnostic criteria for HCM.
Abstract

Keywords:
QRS durationhypertrophic cardiomyopathyleft ventricular massleft ventricular non-compactionpost-hypertensive hypertrophy

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