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Updated: Nov 9, 2025

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
[Endovascular management of chronic limb ischemia. Experience in 48 procedures]
J Ignacio Torrealba1, J Francisco Vargas1, Leopoldo A Mariné1
1Departamento cirugía vascular, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Insights
Endovascular therapy for chronic limb ischemia shows high wound healing and amputation-free rates. This minimally invasive approach offers a viable alternative to open surgery for distal arterial disease.
Area of Science:
- Vascular Surgery
- Endovascular Interventions
- Peripheral Arterial Disease
Background:
- Chronic limb ischemia (CLI) is associated with significant limb loss and mortality.
- Open surgery is the standard treatment for distal CLI.
- Endovascular surgery offers a less invasive alternative with comparable outcomes.
Purpose of the Study:
- To evaluate the outcomes of endovascular treatment for distal arterial disease.
- To report on a cohort of patients treated at our institution.
Main Methods:
- Retrospective review of endovascular procedures for distal lower extremity disease (2016-2019).
- Analysis of patient demographics, comorbidities, presentation, interventions, complications, and outcomes.
- Primary outcomes: wound healing, reintervention, freedom from major amputation.
Main Results:
- 48 limbs in 41 patients (mean age 75) treated; 73% presented with major wounds.
- 85% wound healing and 90% freedom from amputation at one year.
- 18% complication rate, 2% perioperative mortality, 76% one-year survival.
Conclusions:
- Endovascular therapy is effective for CLI, achieving high rates of wound healing and limb salvage.
- The procedure demonstrates low perioperative mortality and manageable complication rates.
- This approach is a valuable option for patients with distal arterial disease.
Background:
Chronic limb ischemia can lead to high rates of limb loss and mortality. Open surgery is the gold standard for treatment of distal disease. Endovascular surgery should have less complications with similar outcomes.
Aim:
To report a cohort of patients with distal arterial disease treated with endovascular surgery at our institution.
Material And Methods:
Review of angioplasty records of patients undergoing distal lower extremity endovascular procedures between 2016 and 2019. Demographics, comorbidities, form of presentation, type of intervention, perioperative complications, and length of stay were analyzed. The primary outcomes were wound healing, reinterventions and freedom from major amputation. Secondary outcomes were overall survival and amputation-free survival.
Results:
Forty-eight limbs of 41 patients with a mean age 75 years (78% males) were treated. Ninety-three percent had hypertension, 88% diabetes, 30% chronic kidney disease. 73% presented with major wounds. Plain balloon and drug coated balloon angioplasties were carried out in 65 and 31% of procedures respectively, with no difference in results. In 46% of the cases, only chronic total occlusions were treated. Wound healing was achieved in 85% of procedures and 90% of patients were free from amputation at one year of follow up. Complications were observed in 18% of procedures, perioperative mortality was 2% and one-year survival was 76%.
Conclusions:
Endovascular therapy achieves high rates of wound healing and freedom from amputation with low perioperative mortality and moderate complication rates.
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