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Published on: July 22, 2020
SELE gene as a characteristic prognostic biomarker of colorectal cancer
Na Li1,2, Honghe Xiao3, Jiangli Shen1
1Department of Anorectal Surgery, Xianyang Central Hospital, Xianyang, China.
Objective:
To investigate the expression and clinical value of the E-selectin gene (SELE) in colorectal cancer (CRC).
Methods:
Using gene expression profiles and clinicopathological data for patients with CRC from The Cancer Genome Atlas, and tumor and adjacent normal tissues from 31 patients with CRC from Xianyang Central Hospital, we studied the correlation between SELE gene expression and clinical parameters using Kaplan-Meier and Cox proportional hazards regression analyses.
Results:
Higher expression of SELE was significantly associated with a poorer prognosis and shorter survival in patients with CRC. The median expression level of SELE was significantly higher in CRC tissues compared with healthy adjacent tissue. Cox regression analysis showed that the prognosis of CRC was significantly correlated with the expression of SELE. Immunohistochemical analysis also showed that positive expression of E-selectin increased significantly in line with increasing TNM stage.Conclusion: This study confirmed that SELE gene expression is an independent prognostic factor in patients with CRC.
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