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Updated: Nov 9, 2025
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
High Expression of miR-483-5p Predicts Chemotherapy Resistance in Epithelial Ovarian Cancer
Yanisa Rattanapan1, Veerawat Korkiatsakul2, Adcharee Kongruang2
1School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Background:
Ovarian cancer is the most deadly cancer that requires novel diagnostics and therapeutics. MicroRNAs are viewed as essential gene regulatory elements involved in different pathobiological mechanisms of many cancers, including ovarian cancer.
Objective:
This study examined the relationship between microRNA (miRNA) expression and response to platinum-based chemotherapy.
Methods:
Genome-wide miRNA expression analysis was conducted using Epithelial Ovarian Cancer (EOC) tissues from 25 patients with 17 malignant tumors and eight benign ovarian tumors. Candidate miRNAs that respond to platinum-based chemotherapy were selected for validation by quantitative RT-PCR.
Results:
Among 2,578 mature human miRNAs, high expression of miR-483-5p correlated with poor responses to platinum-based chemotherapy in EOC patients. Furthermore, high levels of miR-483-5p in the resistant group suppressed expression of the apoptotic regulator TAOK-1.
Conclusion:
A possible marker for the prediction of chemotherapy response and resistance in patients may be miR-483-5p. Choosing the right treatment for each patient with EOC can avoid the risk of developing chemotherapy resistance.
Insights
High levels of microRNA (miRNA) miR-483-5p indicate poor response to platinum-based chemotherapy in ovarian cancer patients. This finding may help predict treatment resistance and guide personalized therapy for epithelial ovarian cancer (EOC).
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Ovarian cancer is a leading cause of cancer-related death, necessitating innovative diagnostic and therapeutic strategies.
- MicroRNAs (miRNAs) are key regulators of gene expression implicated in the pathogenesis of various cancers, including ovarian cancer.
Purpose of the Study:
- To investigate the correlation between microRNA (miRNA) expression profiles and patient response to platinum-based chemotherapy in epithelial ovarian cancer (EOC).
Main Methods:
- Genome-wide miRNA expression profiling was performed on EOC tissues from 25 patients.
- Candidate miRNAs associated with chemotherapy response were validated using quantitative RT-PCR.
Main Results:
- High expression of miR-483-5p was significantly correlated with poor response to platinum-based chemotherapy in EOC patients.
- Elevated miR-483-5p levels in chemotherapy-resistant tumors were associated with suppressed expression of the pro-apoptotic gene TAOK-1.
Conclusions:
- miR-483-5p may serve as a predictive biomarker for chemotherapy response and resistance in ovarian cancer patients.
- Identifying patients with high miR-483-5p could enable tailored treatment strategies to prevent chemotherapy resistance.
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