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Updated: Nov 9, 2025

Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
Preparation of Artificial Hexaplex Composed of Non-Natural Nucleic Acid
Koki Makino1, Yuhei Hattori1, Hiromu Kashida1
1Deparment of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Nagoya, Japan.
Abstract:
This article describes synthetic procedures for acyclic D-threoninol nucleic acid tethering of bifacial nucleobases. Because these nucleobases have complementary hydrogen bonding sites on both sides, their oligomers can form a hexaplex. These hexaplexes are suitable for use as metal or pH sensors and as supramolecular motifs. © 2021 Wiley Periodicals LLC. Basic Protocol 1: Synthesis of D-threoninol backbone Basic Protocol 2: Synthesis of D-aTNA tethering cyanuric acid Basic Protocol 3: Synthesis of D-aTNA tethering a 2-aminopyrimidine moiety Basic Protocol 4: Synthesis of D-aTNA tethering a 2,4,6-triaminopyrimidine moiety Basic Protocol 5: Synthesis of D-aTNA oligomer tethering cyanuric acid, 2-aminopyrimidine, or 2,4,6-triaminopyrimidine.
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