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Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger
Mabel Qi He Leow1, Qishi Zheng2, Luming Shi2
1Biomechanics Laboratory, Singapore General Hospital, Singapore, Singapore.
The Cochrane Database of Systematic Reviews
|April 13, 2021
Summary
Non-steroidal anti-inflammatory drug (NSAID) injections offer little benefit for trigger finger compared to glucocorticoid injections. Both treatments showed no significant difference in symptom resolution, pain, or adverse events at 24 weeks.
Area of Science:
- Orthopedics
- Rheumatology
- Pharmacology
Background:
- Trigger finger, a common hand condition, involves impaired flexor tendon movement due to inflammation and swelling.
- Non-surgical treatments include NSAIDs, splinting, and corticosteroid injections.
Purpose of the Study:
- To compare the efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) versus glucocorticoids for trigger finger treatment.
- To evaluate outcomes such as symptom resolution, pain, and adverse events.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) and quasi-RCTs.
- Searched multiple databases up to September 2020, including CENTRAL, MEDLINE, and Embase.
- Included adult participants with trigger finger comparing NSAIDs (oral, topical, or injection) with placebo or glucocorticoids.
Main Results:
- Two RCTs (231 participants) compared NSAID injections with glucocorticoid injections.
- NSAID injections showed little to no benefit over glucocorticoid injections regarding symptom resolution, pain, or function at 12-24 weeks.
- Evidence was low to very low certainty due to bias and imprecision.
Conclusions:
- NSAID injections provide minimal to no advantage over glucocorticoid injections for treating trigger finger.
- No significant differences were observed in symptom resolution, recurrence, pain, or adverse events between NSAIDs and glucocorticoids.
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