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Related Experiment Video

Updated: Nov 9, 2025

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Preoperative imaging optimized for epiretinal membrane surgery.

Elise Philippakis1, Raphaël Thouvenin2, Sarra Gattoussi2

  • 1Ophthalmology Department, AP-HP, Hôpital Lariboisière, Université de Paris, 75010, Paris, France. elise.philippakis@aphp.fr.

International Journal of Retina and Vitreous
|April 14, 2021
PubMed
Summary
This summary is machine-generated.

Blue-reflectance (BR) and En Face optical coherence tomography (OCT) best visualize epiretinal membrane (ERM) morphology preoperatively. Intraoperative digital images (IDI) after blue staining showed similar ERM features but were less effective at visualizing ERM edges.

Keywords:
Blue reflectanceBlue stainingEn face OCTEpiretinal membraneIntraoperative visualization

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Surgery

Background:

  • Epiretinal membranes (ERMs) are a common cause of visual impairment.
  • Accurate preoperative visualization of ERM morphology is crucial for surgical planning.
  • Current imaging techniques have limitations in depicting ERM details.

Purpose of the Study:

  • To compare the effectiveness of various preoperative imaging modalities for visualizing primary epiretinal membranes (ERMs).
  • To compare these preoperative images with intraoperative digital images (IDI) obtained after blue staining.
  • To evaluate the utility of different imaging techniques in surgical guidance for ERM removal.

Main Methods:

  • Retrospective review of 70 eyes operated for primary ERM.
  • Preoperative imaging included color fundus photography (CFP), En Face spectral-domain optical coherence tomography (OCT), infrared (IR), and blue-reflectance (BR) scanning laser ophthalmoscopy.
  • Images were scored for ERM visualization, and compared with intraoperative digital images (IDI) after blue staining.

Main Results:

  • Blue-reflectance (BR) and En Face OCT provided the best visualization of ERM morphology, achieving high scores in a significant percentage of cases.
  • En Face OCT and BR imaging visualized ERM details in 68.5% and 62.1% of eyes, respectively, compared to CFP (17.9%) and IR (13.6%).
  • Intraoperative digital images (IDI) showed similar ERM morphology to preoperative scans but failed to visualize ERM edges in 37.5% of cases.

Conclusions:

  • Blue-reflectance (BR) and En Face OCT are superior preoperative imaging modalities for visualizing epiretinal membrane (ERM) morphology.
  • While intraoperative digital images (IDI) after blue staining offer comparable morphology, they are less effective for visualizing ERM edges.
  • Future intraoperative systems could integrate BR and En Face OCT with IDI for enhanced surgical guidance in ERM removal.