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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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The risk and severity of stroke in patients with atrial fibrillation and gout: A National Representative Database

Faris Haddadin1, Ana B Arevalo2, Ahmad Jabri3

  • 1Section of Cardiology Baylor College of Medicine Houston TX USA.

Journal of Arrhythmia
|April 14, 2021
PubMed

Insights

Gout increases the risk of new stroke in patients with atrial fibrillation (AF). However, gout presence did not affect stroke severity in AF patients.

Area of Science:

  • Cardiology
  • Rheumatology
  • Neurology

Background:

  • Gout is linked to left atrium remodeling and inflammation, contributing to atrial fibrillation (AF).
  • Limited evidence exists on gout's impact on stroke risk in AF patients.

Purpose of the Study:

  • To assess the incidence of gout and its association with stroke risk in patients diagnosed with AF.

Main Methods:

  • Retrospective cohort study utilizing the 2016 US National Inpatient Sample (NIS).
  • Analysis based on ICD-10 codes to identify patients with AF and gout.
  • Outcomes measured included the risk and severity of new stroke.

Main Results:

  • Over 3.8 million patients with AF were identified, with 240,875 having a history of gout.
  • Patients with AF and gout exhibited a significantly higher risk of new stroke (OR 2.07, P < .001).
  • This elevated stroke risk persisted after adjusting for CHADS2VASC score and other comorbidities (OR 1.10, P = .041). Gout did not correlate with mortality or need for mechanical ventilation.

Conclusions:

  • Gout is associated with an increased risk of new stroke in patients with AF.
  • Gout presence was not linked to stroke severity in this patient cohort.
  • Gout may serve as a risk factor or marker for stroke in individuals with AF.
Abstract

Keywords:
atrial fibrillationgoutstroke

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