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In vitro and in vivo assessment of hydroxypropyl cellulose as functional additive for enabling formulations

Rafael D Bachmaier1, Marius Monschke1, Thilo Faber1

  • 1Department of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, 53121 Bonn, Germany.

International Journal of Pharmaceutics: X
|April 14, 2021
PubMed

Keywords:
API, active pharmaceutical ingredientASD, amorphous solid dispersionAUC, area under the curveAcN, acetonitrileAmorphous solid dispersionBCS, biopharmaceutical classification systemBiphasic dissolutionDMSO, dimethyl sulfoxideDSC, differential scanning calorimetryFaSSIF, fasted state simulated intestinal fluidGI, gastrointestinalHME, hot-melt extrusionHPCHPC, hydroxypropyl celluloseHPMCHPMC, hydroxypropyl methyl celluloseHot-melt extrusionITZ, itraconazoleKTZ, ketoconazoleNCE, new chemical entityOH-ITZ, hydroxy-itraconazolePM, physical mixtureSD, spray-dryingTG, glass transition temperatureXRPD, x-ray powder diffraction

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