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Short-, Mid-, and Long-Term Associations Between PM2.5 and Stroke Incidence in Taiwan
Chun-Pai Yang1, Chung-Yi Li, Winn-Jung Huang
1From the Department of Neurology (Dr Yang); Department of Medical Research (Dr Yang, Ms Lu, Dr Yan), Kuang Tien General Hospital, Taichung, Taiwan; Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan (Dr Yang, Dr Yan); Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Dr Li); Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan (Dr Li); Department of Safety, Health, and Environmental Engineering, Hung Kuang University, Taichung, Taiwan (Dr Huang); Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (Dr Yu); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Dr Yang); Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan (Dr Lang); National Yang Ming Chiao Tung University, Taipei, Taiwan (Dr Lang); Department of Endocrinology and Metabolism, Kuang Tien General Hospital, Taichung, Taiwan (Dr Yan).
Objective:
To investigate the association between the risk of stroke and exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) over various exposure periods.
Methods:
This was a nationwide population-based case-control study in which 10,035 incident patients with a primary diagnosis of ischemic stroke each were matched with two randomly selected controls for sex, age, Charlson Comorbidity Index, year of stroke diagnosis, and level of urbanization. Multiple logistic models adjusted for potential confounders were used to assess the association of PM2.5 with ischemic stroke incidence.
Results:
There were significant short-term, medium-term, and long-term relationships between PM2.5 exposure and ischemic stroke incidence.
Conclusions:
This study supports existing evidence that PM2.5 should be considered a risk factor for ischemic stroke.
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