Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

50
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
50
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

119
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
119
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

72
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
72
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

221
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
221
Hemodialysis III: Nursing Management01:25

Hemodialysis III: Nursing Management

380
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
380
Body Water Content and Fluid Compartments01:19

Body Water Content and Fluid Compartments

3.3K
Life's biochemical processes occur within aqueous solutions. Solutes are substances that are dissolved within these solutions. The human body contains a variety of solutes, which can differ across various body parts. These can encompass proteins—such as those responsible for clotting and carbohydrate transport—as well as electrolytes. In medicine, an electrolyte is often described as a mineral ion derived from a salt possessing an electric charge. Examples include sodium ions...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Evaluating Kidney Function in older Adults - how to ensure accurate Assessment].

Deutsche medizinische Wochenschrift (1946)·2025
Same author

Surface CD69-Negative CD4 and CD8 Bone Marrow-Resident Human Memory T Cells.

European journal of immunology·2025
Same author

[Multimorbidity and the Kidney].

Deutsche medizinische Wochenschrift (1946)·2025
Same author

Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease.

Gut microbes·2025
Same author

Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis.

Molecular and cellular pediatrics·2024
Same author

[Adapting prescription in CKD].

MMW Fortschritte der Medizin·2024
Same journal

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

["Not everything that looks like a tumor..." - Pulmonary tularemia with hilar lymphadenopathy].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Emergency management of sickle cell disease].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Hereditary dehydrated stomatocytosis (= hereditary xerocytosis) - Interesting hummingbird or clinically relevant diagnosis?]

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[Diagnosis of Congenital Hemolytic Anemias in Adults].

Deutsche medizinische Wochenschrift (1946)·2026
Same journal

[46-year-old female patient with right upper abdominal pain].

Deutsche medizinische Wochenschrift (1946)·2026
See all related articles

Related Experiment Video

Updated: Nov 9, 2025

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.8K

[Fluid management in older persons].

Ute Hoffmann

    Deutsche Medizinische Wochenschrift (1946)
    |April 14, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Older adults are more prone to dehydration (exsiccosis) and fluid overload (hydropic decompensation), leading to severe health issues. This review covers causes, consequences, and management strategies for these age-related fluid balance disturbances.

    More Related Videos

    Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
    07:59

    Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

    Published on: July 28, 2018

    11.5K
    Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
    07:17

    Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

    Published on: August 17, 2022

    2.9K

    Related Experiment Videos

    Last Updated: Nov 9, 2025

    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
    06:59

    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

    Published on: November 9, 2016

    30.8K
    Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
    07:59

    Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol

    Published on: July 28, 2018

    11.5K
    Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
    07:17

    Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis

    Published on: August 17, 2022

    2.9K

    Area of Science:

    • Gerontology
    • Internal Medicine
    • Clinical Physiology

    Background:

    • Exsiccosis and hydropic decompensation are prevalent in elderly populations.
    • These conditions are linked to significant complications, increased illness, and higher mortality rates.

    Purpose of the Study:

    • To detail age-associated causes and consequences of exsiccosis and hydropic decompensation.
    • To provide a practical framework for prevention, diagnosis, and treatment of these fluid balance disorders in older adults.

    Main Methods:

    • Literature review focusing on age-related physiological changes affecting fluid balance.
    • Synthesis of current evidence on the pathophysiology, clinical presentation, and management of dehydration and fluid overload in the elderly.

    Main Results:

    • Identified key risk factors for exsiccosis and hydropic decompensation in older individuals.
    • Outlined common complications and prognostic indicators associated with these conditions.
    • Summarized evidence-based preventive and therapeutic interventions.

    Conclusions:

    • Early recognition and management of fluid and electrolyte disturbances are critical in geriatric care.
    • A comprehensive approach addressing causes, consequences, and tailored interventions can mitigate morbidity and mortality associated with exsiccosis and hydropic decompensation.