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Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
Published on: October 21, 2009
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Textile-based sandwich scaffold using wet electrospun yarns for skin tissue engineering
Chen Jiang1, Kan Wang2, Yi Liu3
1School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA; Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA.
Journal of the Mechanical Behavior of Biomedical Materials
|April 15, 2021
Summary
Researchers developed a novel textile-based scaffold using polycaprolactone (PCL) to mimic human tissue's strain-stiffening properties. This scaffold supports cell growth and has tunable mechanical properties suitable for tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Textile Engineering
Background:
- Mimicking the strain-stiffening property of human tissues using synthetic materials is a significant challenge in scaffold fabrication.
- Most synthetic materials exhibit strain-softening behavior, unlike biological tissues.
Purpose of the Study:
- To propose and validate a textile-based sandwich scaffold capable of mimicking the strain-stiffening behavior of human tissues.
- To engineer scaffolds with tunable mechanical properties and support cellular functions for tissue regeneration.
Main Methods:
- Fabrication of polycaprolactone (PCL) yarns via wet electrospinning.
- Crocheting PCL yarns into a textile fabric and embedding it within electrospun mats to create a sandwich scaffold.
- Characterization of mechanical properties and cell proliferation/infiltration capabilities.
Main Results:
- The textile-based sandwich scaffold demonstrated strain-stiffening behavior, unlike typical strain-softening synthetic materials.
- Tunable mechanical properties (maximum stress, strain, elastic modulus) were achieved, falling within the range of human skin.
- The scaffold successfully supported cell proliferation and infiltration after optimization.
Conclusions:
- The developed textile-based sandwich scaffold effectively mimics the physical, mechanical, and biological properties of human skin.
- This approach offers a promising strategy for fabricating advanced scaffolds in tissue engineering.
- The tunable nature of the scaffold allows for adaptation to various tissue regeneration requirements.
