Related Experiment Video
Updated: Nov 9, 2025
08:33
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
8.4K
Paraproteinemias and Peripheral Nerve Disease
Yaowaree Leavell1, Susan C Shin1
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Clinics in Geriatric Medicine
|April 16, 2021
Summary
This review covers major paraprotein-related peripheral neuropathies, detailing their clinical features, diagnosis, and treatment. It highlights key conditions like monoclonal gammopathy and amyloidosis for better understanding and management.
Area of Science:
- Neurology
- Hematology
- Genetics
Background:
- Paraprotein-related peripheral neuropathies are a diverse group of disorders.
- Accurate diagnosis and management are crucial for patient outcomes.
Purpose of the Study:
- To provide a comprehensive overview of major paraprotein-related peripheral neuropathies.
- To detail clinical features, diagnosis, and treatment strategies for these conditions.
Main Methods:
- Literature review of paraprotein-related peripheral neuropathies.
- Synthesis of information on epidemiology, demographics, systemic findings, and electrophysiologic features.
- Review of pharmacologic treatments for transthyretin amyloid polyneuropathy.
Main Results:
- Overview of clinical presentation, diagnostic criteria, and treatment options for conditions including monoclonal gammopathy of undetermined significance, Waldenström macroglobulinemia, POEMS syndrome, multiple myeloma, transthyretin amyloidosis, and light chain amyloidosis.
- Detailed presentation of epidemiological and electrophysiologic characteristics for each neuropathy.
- Summary of current pharmacologic treatments for transthyretin amyloid polyneuropathy.
Conclusions:
- Paraprotein-related peripheral neuropathies encompass a range of disorders with distinct features.
- Understanding these features is essential for timely diagnosis and effective treatment.
- Further research into targeted therapies may improve patient prognosis.
More Related Videos
Related Concept Videos
01:30Peripheral Artery Disease I: Introduction
136
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
136
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
124
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
124
01:24Peripheral Nervous System: Ganglia and Nerves
3.6K
The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
3.6K
01:26Peripheral Artery Disease IV: Nursing Management
122
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
122
01:37Neural Regulation
41.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
41.1K
01:28Disorders of the Nervous Tissue
2.2K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.2K