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Related Concept Videos

Skin Cancer01:30

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Tumor Lysis Syndrome: Introduction of a Cutaneous Variant and a New Classification System.

Philip R Cohen1, Victor G Prieto2, Razelle Kurzrock3

  • 1Dermatology, San Diego Family Dermatology, National City, USA.

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|April 16, 2021
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Summary

Tumor lysis syndrome (TLS) is an oncologic emergency. A new variant, cutaneous TLS, is proposed, characterized by ulcerated skin metastases following cancer treatment.

Keywords:
cancercarcinomacutaneoushematologiclysismalignancymetastaticsolidsyndrometumor

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Area of Science:

  • Oncology
  • Dermatology
  • Nephrology

Background:

  • Tumor lysis syndrome (TLS) is a critical oncologic emergency.
  • TLS is characterized by metabolic derangements and renal injury.
  • It commonly affects hematologic malignancies but can occur in solid tumors.

Purpose of the Study:

  • To report a case of metastatic salivary duct carcinoma with cutaneous metastases.
  • To propose a new classification of TLS including a cutaneous variant.
  • To highlight the potential increase in therapy-associated cutaneous TLS with targeted therapies.

Main Methods:

  • Case report of a patient with metastatic salivary duct carcinoma.
  • Clinical observation of cutaneous metastases (carcinoma erysipeloides).
  • Microscopic examination of metastatic tumor cells in the dermis.

Main Results:

  • The patient experienced an excellent response to antineoplastic therapy.
  • Cutaneous metastases ulcerated and shed after treatment.
  • This response suggests a novel form of TLS affecting the skin.

Conclusions:

  • A new variant, cutaneous tumor lysis syndrome, is proposed.
  • This variant may become more prevalent with advanced targeted therapies.
  • Early recognition and management of cutaneous TLS are crucial.