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Constructing the rodent stereotaxic brain atlas: a survey
Zhao Feng1,2, Anan Li1,2, Hui Gong3,4
1Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MOE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, 430074, China.
This study reviews the history and key concepts of stereotaxic brain atlases, essential neuroscience tools. Future trends include single-cell resolution and micron-level precision for enhanced brain mapping.
Area of Science:
- Neuroscience
- Neuroanatomy
- Scientific Atlasing
Background:
- Stereotaxic brain atlases are crucial references in neuroscience research.
- Understanding their development and core concepts is vital for accurate brain mapping.
Observation:
- The study clarifies key elements: brain image, atlas, and stereotaxis.
- Four technical indices for atlas evaluation are refined: staining quality, delineation granularity, spatial resolution, and location precision.
Findings:
- Current technologies in image acquisition, stereotaxic coordinate construction, image processing, and anatomical recognition are discussed.
- Trends in brain atlas illustration and publishing are highlighted.
Implications:
- Future stereotaxic brain atlases will likely feature single-cell resolution and micron-level location precision.
- These advancements promise to significantly benefit the field of neuroscience and brain research.
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