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    This study developed an implantable system to enhance plantar cutaneous feedback, crucial for stable walking. The system successfully augmented feedback during treadmill walking in rats, showing potential for gait rehabilitation research.

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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Biomechanics

    Background:

    • Plantar cutaneous feedback is vital for gait stability and efficiency.
    • Nervous system trauma can impair this feedback, affecting motor control.
    • Augmenting plantar feedback may offer therapeutic benefits for gait disorders.

    Purpose of the Study:

    • To test a fully implantable neural system for augmenting plantar cutaneous feedback.
    • To evaluate the system's functionality in a rodent model during locomotion.
    • To assess the potential of this technology for investigating gait impairments.

    Main Methods:

    • Developed and implanted a wireless neural recording and stimulation system.
    • Recorded electromyograms from the medial gastrocnemius for stance phase detection.
    • Applied biphasic stimulation pulses to the distal-tibial nerve during the stance phase.
    • Utilized Bluetooth low energy for communication and Qi-standard for wireless charging.
    • Assessed system performance during treadmill locomotion in an intact rat.

    Main Results:

    • The system successfully delivered stimulation during the stance phase of gait (onset at ~47.58%, offset at ~83.49%).
    • Evoked action potentials exhibited conduction velocities consistent with afferent cutaneous feedback.
    • Demonstrated reliable wireless charging and system reset functionalities.
    • The implantable system proved effective in a live animal model.

    Conclusions:

    • The developed implantable system can effectively augment plantar cutaneous feedback.
    • This technology serves as a valuable neural interface for studying gait.
    • It holds promise for future research into gait rehabilitation strategies.