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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Updated: Nov 9, 2025

Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
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The bone bridge significantly affects the decrease in bone mineral density measured with quantitative computed

So Yun Lee1, Ran Song1, Hyung In Yang1

  • 1Department of Rheumatology, College of Medicine, Kyung Hee University, Seoul, Korea.

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|April 16, 2021
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Summary
This summary is machine-generated.

Ankylosing spondylitis (AS) patients with spinal bone bridges show reduced bone density. Immobilization from bone fusion contributes to lower bone mineral density (BMD) in AS.

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Area of Science:

  • Orthopedics
  • Rheumatology
  • Radiology

Background:

  • Ankylosing spondylitis (AS) is characterized by spinal bone fusion.
  • Spinal inflammation is a presumed cause of reduced bone mineral density (BMD) in AS.
  • Immobilization is a known risk factor for BMD reduction.

Purpose of the Study:

  • To investigate the relationship between spinal immobilization due to syndesmophytes and BMD reduction in AS patients.
  • To determine if bone bridge formation correlates with decreased BMD in the lumbar spine.

Main Methods:

  • Retrospective analysis of 47 male AS patients diagnosed via modified New York criteria.
  • Correlation analysis between radiographic bone bridge presence and quantitative computed tomography (QCT)-measured BMD in the lumbar spine (L1-L4).
  • Assessment of bone bridge score and Bath Ankylosing Spondylitis Radiology Index (BASRI) spinal mobility scores.

Main Results:

  • 63.8% of patients had osteopenia or osteoporosis.
  • Bone bridge formation negatively correlated with lumbar BMD (p < 0.05).
  • Increased bone bridge scores correlated with reduced spinal mobility (BASMI flexion), and decreased BMD correlated with reduced spinal mobility (p < 0.05).

Conclusions:

  • Vertebral immobilization from bone bridge formation contributes to decreased BMD in ankylosing spondylitis.
  • Reduced spinal mobility is linked to both bone bridge formation and lower BMD in AS.