Related Experiment Video
Updated: Nov 9, 2025

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
[Brodie's abscess, a pathology difficult to diagnose].
Isadora Silva C1, María Jesús Figueroa G2, Ismael Cañete C2
1Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Brodie's abscess, a rare subacute osteomyelitis, presents with non-specific symptoms, making clinical suspicion crucial for early diagnosis. Prompt treatment involving debridement and antibiotics is vital for favorable outcomes in pediatric bone infections.
Area of Science:
- Pediatric Infectious Diseases
- Orthopedic Surgery
- Diagnostic Imaging
Background:
- Acute osteoarticular infections in children are rare but require prompt diagnosis and treatment to prevent complications.
- Brodie's abscess (BA) is an uncommon, subacute form of osteomyelitis that poses diagnostic challenges.
Observation:
- A 14-year-old presented with persistent thigh pain, normal initial X-rays, and unremarkable inflammatory markers.
- Ultrasound revealed cortical irregularity, and MRI indicated a lesion in the femoral diaphysis, raising concerns for tumor or infection.
- Staphylococcus aureus was identified via bone biopsy, confirming a multi-sensitive infection.
Findings:
- Despite non-specific clinical and laboratory findings, Brodie's abscess was diagnosed in a pediatric patient.
- The case highlights the importance of advanced imaging and biopsy in diagnosing subacute osteomyelitis.
- Successful management involved surgical debridement and intravenous antibiotics.
Implications:
- Non-specialist physicians should consider Brodie's abscess in the differential diagnosis for persistent bone pain with imaging abnormalities, even with normal inflammatory markers.
- Bone biopsy is essential for differentiating infectious processes from bone tumors.
- Early suspicion and diagnosis of Brodie's abscess can prevent long-term sequelae in pediatric patients.
Related Concept Videos
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Acute Pyelonephritis II: Diagnostic Studies and Management
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

