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Updated: Nov 9, 2025
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Bonding a titanium plate and soft tissue interface by using an adhesive bone paste composed of α-tricalcium phosphate
1Polymers and Biomaterials Field, Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Abstract:
Adhesive bone pastes for dental implants and soft tissue interfaces were developed using α-tricalcium phosphate (α-TCP) and α-cyclodextrin (α-CD)/nonanyl group-modified poly(vinyl alcohol) (C9-PVA) inclusion complex solution (ICS). The thixotropic solution of α-CD/C9-PVA ICS was prepared by mixing α-CD and C9-PVA in deionized water. The α-CD/C9-PVA bone paste led to the highest bonding and shear adhesion between commercial pure titanium plates and soft tissue like collagen casing. Moreover, the compressive strength of these pastes reached 14.1 ± 3.8 MPa within 24 h incubation. Young's modulus of the α-CD/C9-PVA bone paste was lower than that of commercial calcium phosphate paste. Furthermore, the surface of α-CD/C9-PVA bone paste demonstrated excellent cell adhesion for cultured L929 fibroblast cells. Overall, the α-CD/C9-PVA bone paste can likely be effectively used to adhere dental implant abutments and soft tissue interfaces.
