[Stimulation of endogenous defense in cancer patients]

A group of 45 patients with carcinoma of the larynx who had already been treated were given a sterile dialysate extracted from the sperm of trout to stimulate their endogenous defence mechanisms. Previous research had shown that specially prepared pre-metastatic lymph nodes injected intracutaneously prolonged the average survival time of cancer patients. Similar results could be obtained by using fish extracts. The dermoreaction after the intracutaneous injection showed the patients' susceptibility to stimulation. The patients who reacted positively lived longer than the ones who reacted negatively and those of a homogeneous control group of the same size who were not vaccinated. Survival times and absence of recidivity were significantly longer in patients with supraglottic tumours, stage III.