[Combined treatment of primary inoperable breast cancer]

The paper is devoted to the clinical characterization and results of therapy of 45 patients with locally advanced, primary inoperable cancer. Most of the women were at the age of 40-60, of them 64% had preserved menstrual ovarian function. Multimodality therapy included radiation therapy combined with chemotherapy (UAM and CMF schemes). The breast and all zones of regional metastasis were irradiated at a single focal dose of 2 Gy, the total focal doses were 67-70 Gy to the breast, 50 Gy to the axillary and supra- and subclavicular areas, and 34-40 Gy to the parasternal area. This therapy was followed by radical mastectomy on 30 patients. A degree of expression of a clinical effect and therapeutic pathomorphosis was emphasized. Proceeding from 2-year long-term results, multimodality therapy including surgical intervention was found appropriate.