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New insights into ANGPTL8 in modulating the development of cardio-metabolic disorder diseases
Xin Su1, Guoming Zhang1, Ye Cheng2
1Department of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, No. 2999 Jinshan Road, Xiamen, 361000, Fujian, China.
Insights
Dyslipidemia, a key factor in cardio-metabolic disorders, is influenced by the ANGPTL8 gene and protein. This review summarizes ANGPTL8's role in regulating glucose and lipid metabolism.
Area of Science:
- Genetics
- Metabolic Diseases
- Biochemistry
Background:
- Dyslipidemia is a significant risk factor for obesity, diabetes mellitus, and cardiovascular diseases (CVD), collectively termed cardio-metabolic disorder diseases.
- Dyslipidemia represents a growing global health concern.
- Genome-wide association studies (GWAS) and experimental research are crucial for understanding the genetic basis of dyslipidemia and identifying related gene loci.
Purpose of the Study:
- To review the modulatory effects of the ANGPTL8 gene and protein in cardio-metabolic disorder diseases.
- To provide insights into the mechanisms by which ANGPTL8 influences glucose and lipid metabolism.
Main Methods:
- Review of existing genome-wide association studies (GWAS).
- Analysis of experimental research on ANGPTL8 function.
- Synthesis of current knowledge on ANGPTL8's role in metabolic regulation.
Main Results:
- The ANGPTL8 gene and its corresponding protein play vital roles in modulating serum glucose and lipid metabolism.
- ANGPTL8 is implicated in the development of cardio-metabolic disorder diseases.
Conclusions:
- ANGPTL8 is a key regulator of glucose and lipid metabolism.
- Understanding ANGPTL8's mechanisms offers potential therapeutic targets for cardio-metabolic disorders.
Abstract:
Dyslipidemia is being identified as the most important factors of several health problems, such as obesity, diabetes mellitus, and cardiovascular diseases (CVD), which are always grouped together as cardio-metabolic disorder diseases. Consistently, dyslipidemia has become one of the most rising crisis of general health. Recently, it is worth noting that both genome-wide association studies (GWAS) and experimental research are being taken advantage to elucidate the potential genetic mechanisms of dyslipidemia and to identify new gene loci which contribute to the development of cardio-metabolic disorder diseases. According to the results, both ANGPTL8 gene and ANGPTL8 protein has been shown to embrace vital functions in modulating serum glucose and lipid metabolism. In the current review, the modulatory effects of ANGPTL8 in cardio-metabolic disorder diseases were summarized. In addition, novel insights which elucidate the potential mechanisms whereby ANGPTL8 affects glucose and lipid metabolism were also provided.
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