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Outcomes and Risk Factors for Cardiovascular Events in Hospitalized COVID-19 Patients

Qian Xu1, Harideep Samanapally2, Pavani Nathala2

  • 1Department of Bioinformatics and Biostatistics, School of Public Health and Information Sciences, University of Louisville, Louisville, KY.

Journal of Cardiothoracic and Vascular Anesthesia
|April 19, 2021
PubMed

Insights

Cardiovascular events are common in hospitalized coronavirus disease 2019 (COVID-19) patients and linked to higher mortality. Risk factors for these events varied between African American and white patients, despite similar outcomes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Hospitalized patients with coronavirus disease 2019 (COVID-19) face significant risks.
  • Cardiovascular events are a serious complication of COVID-19, impacting patient outcomes.

Purpose of the Study:

  • To analyze cardiovascular event outcomes and risk factors in COVID-19 patients.
  • To conduct a subgroup analysis in African American populations to assess racial influences on outcomes and risk factors.

Main Methods:

  • Retrospective cohort analysis of 700 adult inpatients hospitalized with COVID-19.
  • Comparison of cardiovascular event occurrences, mortality rates, and risk factors between different demographic groups, including African Americans and white patients.

Main Results:

  • 18% of patients experienced cardiovascular events, with significantly higher mortality (45.2%) compared to those without (8.7%).
  • Male sex, race, lower oxygen saturation, higher potassium, lower albumin, and cardiovascular comorbidities were associated with cardiovascular events.
  • African American patients had unique risk factors including lower serum albumin and neoplastic/immune-compromised diseases, while white patients showed associations with oxygen saturation and comorbidity count.

Conclusions:

  • Cardiovascular events are prevalent in hospitalized COVID-19 patients and associated with worse outcomes.
  • Outcomes for cardiovascular events were similar between African American and white patients post-analysis.
  • Distinct and shared risk factors for cardiovascular events exist across racial groups in COVID-19 patients.
Abstract

Keywords:
COVID-19SARS-CoV-2cardiovascularcoronavirusoutcomerisk factors

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