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Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance
T R Browne1, G K Szabo, J E Evans
1Department of Neurology, Boston University School of Medicine, MA.
Neurology
|July 1, 1988
Abstract:
Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.