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Updated: Nov 8, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Merging kinetic resolution with C-H activation: an efficient approach for enantioselective synthesis
Sumit1, Devesh Chandra1, Upendra Sharma1
1Chemical Technology Division, CSIR-IHBT, Palampur, HP 176 061, India. upendraihbt@gmail.com upendra@ihbt.res.in and Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
Abstract:
In the last two decades tremendous progress has been made in transition-metal (TM)-catalyzed C-H bond functionalization, paving the way to design complex molecules. Despite significant advances, enantioselective C-H activation is still in the age of infancy. For the enantioselective synthesis, several TM catalyst based approaches are well known, including kinetic resolution (KR) and its advanced versions [dynamic kinetic resolution (DKR) and parallel kinetic resolution (PKR)]. These strategies have recently been successfully applied synergetically with the TM catalyzed C-H activation to achieve enantioselective synthesis in a more economical and sustainable way. This review will summarize the recent advancements made towards merging KR with TM-catalysed C-H activation for enantioselective synthesis.
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