Doped-carbon dots: Recent advances in their biosensing, bioimaging and therapy applications

As a fascinating class of fluorescent carbon dots (CDs), doped-CDs are now sparked intense research interest, particularly in the diverse fields of biomedical applications due to their unique advantages, including low toxicity, physicochemical, photostability, excellent biocompatibility, and so on. In this review, we have summarized the most recent developments in the literature regarding the employment of doped-CDs for pharmaceutical and medical applications, which are published over approximately the past five years. Accordingly, we discuss the toxicity and optical properties of these nanomaterials. Beyond the presentation of successful examples of the application of these multifunctional nanoparticles in photothermal therapy, photodynamic therapy, and antibacterial activity, we further highlight their application in the cellular labeling, dual imaging, and in vitro and in vivo bioimaging by use of fluorescent-, photoacoustic-, magnetic-, and computed tomography (CT)-imaging. The potency of doped-CDs was also described in the biosensing of ions, small molecules, and drugs in biological samples or inside the cells. Finally, the advantages, disadvantages, and common limitations of doped-CD technologies are reviewed, along with the future prospects in biomedical research. Therefore, this review provides a concise insight into the current developments and challenges in the field of doped-CDs, especially for biological and biomedical researchers.