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Related Experiment Video

Updated: Nov 8, 2025

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
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Meniscal Salvage: Where We Are Today.

Ashley B Anderson1, Joel Gaston, Lance E LeClere

  • 1From the Division of Orthopaedics, Department of Surgery, Walter Reed National Military Medical Center, Uniformed Services University, Bethesda, MD (Anderson and Dickens), Geneva Foundation, Tacoma, WA (Gaston), the Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD (Gaston), and United States Naval Academy, Naval Health Clinic Annapolis, Annapolis, MD (LeClere).

The Journal of the American Academy of Orthopaedic Surgeons
|April 20, 2021
PubMed
Summary

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Meniscal injuries disrupt knee function, prompting surgical repair. Current treatments aim to preserve the meniscus, but future options like transplantation and bioprinting offer improved outcomes for knee health.

Area of Science:

  • Orthopaedic surgery
  • Biomedical engineering
  • Regenerative medicine

Background:

  • The menisci are crucial fibrocartilaginous knee structures for load support.
  • Meniscal injury alters knee biomechanics, often necessitating surgical intervention.
  • Knee arthroscopy with meniscus débridement is a prevalent orthopaedic procedure.

Purpose of the Study:

  • To review current and emerging meniscal salvage treatments.
  • To explore options for preserving knee function and limiting osteoarthritis progression.
  • To discuss meniscus transplantation, synthetic arthroplasty, and bioprinting.

Main Methods:

  • Literature review of meniscal repair and replacement strategies.
  • Analysis of current surgical techniques and their outcomes.

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  • Exploration of future regenerative and reconstructive approaches.

    • Main Results:

    • Meniscal preservation is vital for knee homeostasis but challenging due to poor vascularity.
    • Meniscectomy is common for irreparable tissue but sacrifices native function.
    • Allografts, scaffolds, and implants are current alternatives for meniscal replacement.

    Conclusions:

    • Salvage treatments aim to restore knee function and patient quality of life.
    • Future strategies focus on promoting healing and advanced tissue replacement.
    • Bioprinted meniscus represents a potential future solution for severe meniscal damage.