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Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
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The emerging association between COVID-19 and acute stroke
Laura K Stein1, Naomi A Mayman2, Mandip S Dhamoon1
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Trends in Neurosciences
|April 21, 2021
Summary
COVID-19 significantly increases stroke risk, affecting 1-6% of hospitalized patients. This review explores the link between coronavirus disease 2019 and stroke, examining potential causes and outcomes.
Area of Science:
- Neurology
- Infectious Diseases
- Cardiovascular Medicine
Background:
- Prior to COVID-19, cerebrovascular disease was rarely associated with human-tropic coronaviruses.
- Emerging evidence indicates a significant increase in stroke incidence among COVID-19 patients.
Purpose of the Study:
- To review the association between COVID-19 and stroke.
- To discuss potential pathogenetic mechanisms underlying COVID-19-related stroke.
- To highlight the need for improved prevention strategies.
Main Methods:
- Literature review of studies investigating COVID-19 and stroke.
- Analysis of reported stroke incidence and outcomes in COVID-19 patients.
- Discussion of proposed etiological factors for stroke in COVID-19.
Main Results:
- 1-6% of hospitalized COVID-19 patients experience stroke.
- Stroke risk in COVID-19 patients may be over sevenfold higher than in influenza patients.
- Outcomes for COVID-19-related stroke are often poorer compared to non-COVID-19 stroke cohorts.
Conclusions:
- The etiology of stroke in COVID-19 is likely multifactorial, involving coagulopathy, inflammation, platelet activation, and endothelial dysfunction.
- Further research is crucial to elucidate the pathogenesis of COVID-19-related stroke.
- Optimizing primary and secondary prevention strategies for COVID-19-associated stroke is essential.
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