Linggui Zhugan Decoction for peripheral vertigo: A protocol for systematic review and meta-analysis

Area of Science:

• Integrative Medicine
• Traditional Chinese Medicine
• Clinical Research

Background:

• Peripheral vertigo presents challenges with current Western treatments, often proving ineffective and causing adverse reactions.
• Linggui Zhugan Decoction (LZD), a traditional Chinese medicine formula, is recognized for its therapeutic properties in warming yang and resolving dampness.
• Existing clinical studies suggest LZD's efficacy in treating peripheral vertigo, yet lack systematic evidence.

Purpose of the Study:

• To objectively evaluate the efficacy and safety of Linggui Zhugan Decoction (LZD) for peripheral vertigo.
• To provide systematic evidence regarding LZD's therapeutic potential in managing peripheral vertigo.

Main Methods:

• A systematic literature search of eight electronic databases will be conducted up to August 2020.
• Two independent researchers will screen randomized controlled trials (RCTs) for inclusion.
• Clinical efficacy will serve as the primary outcome measure, with data synthesized using RevMan V.5.3 and risk of bias assessed via Cochrane's tool.

Main Results:

• This systematic review will synthesize current evidence on the use of Linggui Zhugan Decoction (LZD) for peripheral vertigo.
• A comprehensive analysis of qualified RCTs will be performed to assess treatment outcomes.

Conclusions:

• The study aims to determine if Linggui Zhugan Decoction (LZD) is an effective treatment for peripheral vertigo.
• Updated evidence will be provided to support or refute the use of LZD in clinical practice for peripheral vertigo.