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Effect of Isolated Obesity on Left Ventricular Function and Structure: A Single-Center Experience
Jamilah AlRahimi1, Abdulbari Aboud2, Abdullah S AlQuhaibi3
1Cardiology, King Faisal Cardiac Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Science, Jeddah, SAU.
Cureus
|April 21, 2021
Summary
Isolated obesity does not significantly impact cardiac function. However, higher body mass index (BMI) in males showed negative correlations with left ventricular mass and end-diastolic volume, potentially indicating early cardiomyopathy development.
Area of Science:
- Cardiology
- Obesity Research
Background:
- Obesity can independently increase cardiac mass and affect cardiac performance.
- Few studies have investigated obesity as an isolated risk factor for cardiac changes.
Purpose of the Study:
- To assess the associations between isolated obesity and heart morphological and functional characteristics.
- To determine if obesity, without other comorbidities, affects cardiac structure and function.
Main Methods:
- Cross-sectional study of 114 adult patients with a body mass index (BMI) > 25 kg/m².
- Exclusion of patients with comorbidities like hypertension, diabetes, or dyslipidemia.
- Echocardiographic assessment of left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), and LV end-diastolic volume index (LVEDVI).
Main Results:
- No significant correlation was found between BMI and LVEF in either males or females.
- In males, higher BMI showed a significant negative correlation with LVMI and LVEDVI.
- No significant correlation between BMI and LVMI or LVEDVI was observed in females.
Conclusions:
- Isolated obesity does not appear to affect overall cardiac function (LVEF).
- Cardiac parameters like LVMI and LVEDVI are negatively correlated with higher BMI in males.
- These findings suggest a potential pathway for obesity-induced cardiomyopathy development in males.
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