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An Unexpected Factor to Wellens Syndrome.

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Factor V Leiden deficiency, a common inherited thrombophilia, may increase arterial thromboembolism risk. This case study highlights a patient with severe coronary artery disease and Factor V Leiden deficiency, suggesting a potential link needing further research.

Keywords:
coronary artery angiographycoronary artery occlusionfactor vgenetics of coronary artery diseaseheterozygous factor v leidenleft anterior descending arteryrisk factors cardiovascular diseaseswellens' syndrome

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Area of Science:

  • Cardiology
  • Genetics
  • Hematology

Background:

  • Factor V Leiden deficiency is the most common inherited thrombophilia.
  • It is an autosomal dominant condition with incomplete penetrance.
  • Its association with arterial thromboembolism is debated, with conflicting evidence regarding coronary artery disease and stroke risk.

Observation:

  • A 53-year-old male presented with Wellens syndrome.
  • He had a history of heterozygous factor V Leiden deficiency and no other identified risk factors for cardiovascular disease.
  • Coronary angiography revealed a total occlusion of the proximal left anterior descending artery.

Findings:

  • The patient required coronary artery bypass grafting due to advanced coronary artery disease.
  • Laboratory tests excluded other known risk factors.
  • This case presents a potential association between factor V Leiden deficiency and severe atherosclerosis.

Implications:

  • This case underscores a potential link between factor V Leiden deficiency and arterial thromboembolism, specifically severe coronary artery disease.
  • Further research is warranted to clarify the association between factor V Leiden deficiency and atherosclerosis.
  • Understanding this link may inform risk stratification and management strategies for affected individuals.