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Metabolic engineering strategy for synthetizing trans-4-hydroxy-L-proline in microorganisms.

Zhenyu Zhang1, Pengfu Liu1, Weike Su1,2

  • 1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, Zhejiang, People's Republic of China.

Microbial Cell Factories
|April 22, 2021
PubMed
Summary

Trans-4-hydroxy-L-proline, a key chiral building block, is now efficiently produced using microbial fermentation and metabolic engineering. This review explores strategies to enhance its production, overcoming limitations of traditional methods.

Keywords:
Biosynthetic pathwayMetabolic engineeringProline hydroxylasesTrans-4-hydroxy-L-proline

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