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Time dependence of whole blood aggregation in response to platelet activating factor (PAF)
R R Taylor1, J Strophair, M Sturm
1Department of Medicine, University of Western Australia, Perth.
Thrombosis and Haemostasis
|April 8, 1988
Abstract:
The aggregation/adhesion response to platelet activating factor (PAF) was studied in diluted whole blood by impedance aggregometry. The extent of aggregation varied directly with the interval between blood sampling and aggregation measurement over the first 30 minutes from sampling, then remained stable for the next 60 minutes of observation. This is an effect opposite to that described for aggregation to PAF in platelet rich plasma which, however, cannot be studied soon after sampling. Time dependence of aggregation is important and comparative measurements should be made during the period of stable aggregability.