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Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention

Jangho Park1, Sangwoo Park2, Yong-Giun Kim2

  • 1Department of Psychiatry, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Scientific Reports
|April 22, 2021
PubMed

Insights

Pre-existing depression did not increase mortality in Korean patients after percutaneous coronary intervention (PCI). However, younger angina patients with depression showed higher all-cause mortality.

Area of Science:

  • Cardiology
  • Psychiatry
  • Public Health

Background:

  • The relationship between pre-existing depression and mortality in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) requires further investigation.
  • Understanding these impacts is crucial for comprehensive patient care and risk stratification.

Purpose of the Study:

  • To evaluate the clinical implications of pre-existing depression on mortality in patients with established coronary artery disease (CAD) who underwent PCI.
  • To compare all-cause death incidence between non-depression and depression groups in angina and acute myocardial infarction (AMI) cohorts.

Main Methods:

  • Utilized National Health Insurance claims data from Korea (2013-2017) for patients undergoing PCI.
  • Stratified patients into angina (n=50,256) and acute myocardial infarction (AMI; n=40,049) groups.
  • Employed propensity score matching to compare all-cause mortality between depression and non-depression groups.

Main Results:

  • After propensity score matching, no significant difference in all-cause death was observed in the overall angina (HR 1.013, 95% CI 0.893-1.151) and AMI (HR 0.991, 95% CI 0.865-1.136) groups.
  • Younger angina patients (under 65 years) with depression exhibited significantly higher all-cause mortality (HR 1.769, 95% CI 1.240-2.525).

Conclusions:

  • Pre-existing depression is not associated with increased mortality in the general Korean population undergoing PCI.
  • Depression poses a higher mortality risk specifically for younger patients with angina undergoing PCI, highlighting a need for targeted interventions.

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